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1501 Superior Avenue 300, Newport Beach, CA 92663, US

Spravato® Treatment in Orange County – Fast-Acting Relief for Depression in Newport Beach, CA

Item: Resiliency Mind + Body Medicine
Rating: 4.9
Author: Clara Boshra

Find Hope When Antidepressants Aren’t Enough

If you or a loved one is suffering from treatment-resistant depression (TRD) or major depressive disorder with suicidal thoughts, Spravato® may offer a new path forward. At Resiliency Mind + Body Medicine in Newport Beach, CA, we provide FDA-approved Spravato® (esketamine) therapy in a safe, structured environment designed for comfort and clinical supervision. Our mission is to help you achieve lasting mental wellness when traditional medications have failed to bring relief.

Spravato® is now available for patients across Orange County, including Irvine, Costa Mesa, Laguna Beach, and beyond.

What is Spravato®?

Spravato® is a nasal spray formulation of esketamine, a medication derived from ketamine. Unlike traditional antidepressants, which target serotonin and norepinephrine, Spravato® works on the glutamate system—specifically the NMDA receptor. This novel mechanism is believed to restore synaptic connections in the brain and promote neuroplasticity, which may help “rewire” patterns associated with depression.

Spravato® is FDA-approved to treat:

Treatment-Resistant Depression (TRD)
Major Depressive Disorder (MDD) with Suicidal Ideation

It is administered under direct medical supervision, making it both powerful and safe when delivered by experienced mental health providers.

Why Choose Resiliency Mind + Body Medicine in Newport Beach?

Our clinic offers a comprehensive, integrative approach to mental health, setting us apart as a destination for advanced psychiatric care in Orange County.

Key Benefits of Receiving Spravato® at Resiliency:

REMS-Certified Facility – We are certified under the FDA’s Risk Evaluation and Mitigation Strategy (REMS) program to safely administer Spravato®.
Experienced Psychiatric Team – Led by Dr. Stefani LaFreniere, MD, our team brings expertise in both psychiatric care and integrative wellness.
Multimodal Care – Spravato® treatment can be combined with CBT, lifestyle coaching, TMS, nutritional support, and other wellness services.
Private, Modern Facility – Located in a quiet corner of Newport Beach, our clinic provides a serene, judgment-free space for healing.
Insurance Accepted – We work with most major insurance plans and offer support in navigating Spravato® coverage eligibility.

What to Expect During Spravato® Treatment

Spravato® is administered in-office twice weekly for the first four weeks, followed by a tapering schedule based on your provider’s recommendation.

A Typical Session Includes:

Pre-Treatment Check-In: Vitals, screening, and discussion with your provider.
Spravato® Nasal Spray: Administered in a comfortable, private room under supervision.
Observation Period: Patients remain in our clinic for 2+ hours while effects are monitored.
Transportation Support: Due to potential temporary sedation or dissociation, patients must arrange for a ride home post-treatment.

Duration & Follow-Up

Induction Phase: 2 treatments/week for 4 weeks
Maintenance Phase: 1 treatment/week or bi-weekly, depending on response

Your treatment plan is customized to your clinical needs, with regular evaluations of your mood, side effects, and progress.

Who Is a Candidate for Spravato®?

Spravato® is not a first-line treatment. It is intended for:

Adults with treatment-resistant depression, who have tried at least two other antidepressants without success
Adults with MDD and suicidal ideation requiring rapid intervention

Spravato® is not appropriate for individuals with:

A history of substance use disorder
Uncontrolled hypertension

Certain cardiovascular or psychiatric conditions (your eligibility is reviewed during a full intake evaluation)

Benefits of Spravato® Treatment

Unlike traditional SSRIs or SNRIs, which may take 4–8 weeks to show effects, many Spravato® patients report symptom relief within hours or days of their first treatment.

Clinical Benefits May Include:

Rapid reduction in suicidal thoughts
Improved mood and motivation
Enhanced emotional regulation
Better response to psychotherapy
Restored sense of hope and functionality

For those in acute crisis or with long-standing depression, Spravato® may be life-changing.

The Science Behind Spravato®

Esketamine, the active ingredient in Spravato®, acts as an NMDA receptor antagonist, influencing glutamate, the most abundant neurotransmitter in the brain. This action is believed to stimulate synaptogenesis (the formation of new synapses), which plays a critical role in repairing the brain’s mood regulation pathways.

Unlike oral antidepressants, Spravato® bypasses the digestive tract and delivers rapid-onset neurochemical changes in the brain—ideal for patients who need fast results.

Our Location – Spravato® in Newport Beach, Orange County

Resiliency Mind + Body Medicine is located in the heart of Newport Beach, serving patients across:

Irvine
Costa Mesa
Laguna Niguel
Huntington Beach
Santa Ana
Orange
And the greater Orange County area

Our facility offers free parking, a welcoming front desk team, and flexible weekday scheduling to make your treatment seamless and supportive.

Frequently Asked Questions (FAQ)

Does insurance cover Spravato®?

Yes, most commercial insurers cover Spravato® if the criteria for treatment-resistant depression are met. Our staff will assist with benefit verification and prior authorizations.

Is Spravato® the same as ketamine?

Spravato® is esketamine, a purified form of ketamine, specifically approved by the FDA for depression and administered only in certified clinics.

Is this the same as ketamine infusions?

No. Spravato® is a nasal spray, not an IV infusion. It is dosed and monitored under strict FDA guidelines.

How soon can I start?

After an intake evaluation and insurance approval, treatment may begin in as little as 1–2 weeks.

What Our Patients Are Saying

Resiliency Mind+Body Medicine & TMS Therapy

4.9

Based on 43 reviews

review us on

Ann

21:11 27 Jun 25

Regina Dizon is the absolute BEST! She has my interest to heal, grow and live a fulfilling life. She is a BLESSING and so is the team!!!!

Thank you all!

Arman Florencio (Constantine)

21:00 25 Jun 25

Friendly staff

Kind and very knowledgeable doctor

Response from the owner 21:53 21 May 25

Thank you for your kind words! We're glad to hear that you had a positive experience with our friendly staff and knowledgeable doctor. Your satisfaction is our priority, and we look forward to serving you again.

D B

17:56 25 Jun 25

So, this place is so amazing. Having dealt with adhd all my life, I finally found a person and place to help me. So professional, intelligent, and kind, Regina has changed my world by prescribing meds that work. Im no longer cussing and yelling at myself in frustration for misplacing, forgetting, or losing things all together from ADHD. My world is calmer and much less insane without the destraction moving from one project to another while forgetting all about the prior! I've never lived this way in 61 years.
My nerves aren't constantly on edge, ready to beat myself up in a fight or flight. I simply do what is next ( like normal people, I suppose).
Greatful isn't a strong enough word for how I feel, but it will do for now. I dont have to get upset with myself or search Google in a panic looking for a better word to take gratefuls place! Im beyond grateful to have found this amazing place and people who care and have changed my life! There's nobody else I can say that about.
Thank you, Regina and crew, for having the patience I never had until now. You've made my world a far better place to be in. I only wish I got here sooner. However, I probably would've forgotten the name of this place, cussed myself out and lost the directions. Better late than never.

Response from the owner 18:02 25 Jun 25

Thank you for sharing your incredible experience with us! We're thrilled to hear how much of a positive impact Regina and our team have had on your life. It’s wonderful to know that you're experiencing a calmer and more organized world after finding the right support. Your heartfelt gratitude means a lot to us, and we're so pleased to have been part of your journey. We're here for you anytime you need us!

Mary Wright

17:30 25 Jun 25

The team here is the absolute best. Dr Heather Wong is the most wonderful and approachable person. She listens and is 100% on your team to find a solution. The support staff is also incredible and is quick to answer any message inquiries. Cant recommend them enough.

Response from the owner 17:40 25 Jun 25

Thank you for your wonderful review, Mary! We’re thrilled to hear about your positive experience with Dr. Wong and our team. It's our mission to provide attentive and responsive care, and we’re glad to know you felt supported. Your recommendation means a lot to us, and we look forward to continuing to serve you!

Candy B

19:53 19 Jun 25

Kelly L

17:16 12 Jun 25

I just began my 2nd round of TMS yesterday at Resiliency. I cannot speak highly enough about this company. Everyone is welcoming, compassionate, professional and helpful. I am so grateful for the quality of care I've received here. If you are suffering from treatment resistant Depression, Trauma, and/or PTSD, call them now! It will absolutely change your life and restore your hope. Recovery is possible here. A happy, healthy quality of life awaits you. Don't give up! Call Resiliency today.

Response from the owner 17:27 12 Jun 25

Thank you so much for your heartfelt review, Kelly. We're thrilled to hear that your experience at Resiliency has been so positive and that you feel welcomed and supported by our team. Your encouragement for others to seek help is truly appreciated, and we’re honored to be part of your recovery journey. We're here for you every step of the way as you continue your TMS treatment. Thank you for trusting us with your care!

amanda herbert

23:28 02 Jun 25

The best mental help I have ever received. They find the truth. They don’t just fill their pockets with money. I feel better.

Response from the owner 23:38 02 Jun 25

Thank you for sharing your positive experience! We're dedicated to providing genuine support and helping our clients find the truth. It's wonderful to hear that you feel better after your time with us. Your feedback motivates us to continue our mission of making a difference in people’s lives.

Kathy Green

18:58 30 May 25

The initial interview went very well with Dr. F.

Response from the owner 19:18 02 Apr 25

Thank you for your positive feedback, Kathy! We're glad to hear that your initial interview with Dr. LaFrenierre went well. We appreciate your support!

jose antonio ojeda

02:59 12 Apr 25

My experience has been positive in my rehabilitation from my depression, with the TMS treatment, I am reducing my medications and feeling better about myself, in addition, the staff is very friendly, especially Jessica, she speaks perfect Spanish and can answer any questions you have, 100% recommended

Response from the owner 02:41 01 Oct 24

Thank you for trusting us with your care!

Tim Hammer

23:52 25 Mar 25

I have had great experiences working with Dr. Lori as well as the receptionist. Everyone is very understanding, compassionate, and easy to talk to! I highly recommend Resiliency Mind+Body Medicine & TMS Therapy!

Response from the owner 02:12 26 Mar 25

Thank you for your wonderful feedback, Tim! We're thrilled to hear about your positive experiences with Dr. Lori and our team. Your recommendation means a lot to us! We look forward to continuing to support you on your journey.

Schedule a Consultation

Ready to take the next step? Schedule a consultation today to learn more about how we can help you achieve your health and wellness goals. Our team is here to provide you with the information you need to make informed decisions about your care.