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Spravato® Treatment in Newport Beach, CA

Spravato, known medically as esketamine, offers a breakthrough in the treatment of severe depression, particularly for those who haven’t found relief with traditional methods. At Resiliency Mind+Body Medicine in Newport Beach, CA, we provide Spravato treatment as part of our comprehensive approach to mental health and wellness.

What is Spravato®?

Spravato® is an innovative nasal spray that targets the NMDA receptors in the brain, which are crucial for learning and memory. Unlike conventional antidepressants that focus on serotonin, norepinephrine, or dopamine, Spravato works by enhancing brain neuroplasticity. This process helps create new neural pathways, allowing individuals to break free from negative thought and behavior patterns and develop healthier ones.

One of the significant advantages of Spravato® is its rapid action, often providing relief from depressive symptoms within hours to days, a much faster response compared to the weeks or months typically required for other antidepressants.

Where Did Spravato® Originate?

Spravato®’s active ingredient, esketamine, is derived from ketamine, an anesthetic that has been used in medicine since the 1960s. Over the decades, research into ketamine’s therapeutic potential in mental health led to the development of Spravato® as a specialized treatment for depression. While closely related, esketamine and ketamine are not identical; Spravato® has been specifically formulated and approved for depressive disorders to maximize its efficacy and safety.

Developed by Johnson & Johnson, Spravato® is an FDA-approved nasal spray administered in our REMS-certified clinic in Newport Beach, CA. It is prescribed for clients experiencing:

  • Major Depressive Disorder
  • Treatment-resistant depression
  • Active suicidal thoughts
  • Long-term passively suicidal thoughts
  • Depressive symptoms


Spravato®® is designed to work effectively with other psychotropic medications and is covered by most insurance plans. Patients can
verify their insurance for detailed coverage information.


The recommended treatment schedule typically involves administration twice a week for the first month, followed by once a week in subsequent months, with ongoing monitoring tailored to individual needs. Our Newport Beach psychiatric team carefully oversees the administration of Spravato®. In conjunction with other therapeutic modalities such as psychotherapy, exercise, writing, breathing techniques, and meditation, Spravato®® has shown remarkable positive outcomes for clients nationwide. Residents of Newport Beach and the surrounding Orange County area now have access to this transformative treatment against the serene backdrop of our picturesque coastlines.

Resiliency Mind+Body Medicine is a REMS-certified clinic in Newport Beach. A Risk Evaluation and Mitigation Strategy (REMS) is a drug safety program mandated by the U.S. Food and Drug Administration (FDA) for certain medications with serious safety concerns. This ensures that the benefits of the medication outweigh its risks. The requirement for a REMS underscores the rigorous safety protocols in place for Spravato®, assuring patients that they are in qualified hands with every treatment administered by our team.


All qualifying clients, including those in our residential programs, outpatient programs, and members of our community, are welcome to experience Spravato® treatment at our Newport Beach, CA, clinic location.


For more information on Spravato® as a treatment option for depression,
contact us today.

FAQ: Spravato® Treatment

What is Spravato® used for?

Spravato® is used to treat adults with treatment-resistant depression (TRD) and depressive symptoms in adults with major depressive disorder (MDD) who have acute suicidal ideation or behavior. It is administered in conjunction with an oral antidepressant.

One of Spravato®’s key advantages is its rapid relief of depressive symptoms, often working within hours to days, which is much faster than traditional oral antidepressants that can take weeks or months.

Yes, studies have indicated that Spravato® can help decrease suicidal thoughts and behaviors, making it a valuable option for individuals struggling with severe depression and acute suicidal ideation.

Spravato® is administered as a nasal spray in a certified healthcare setting, such as our REMS-certified clinic. This allows for convenience and flexibility during treatment sessions.

Spravato® has demonstrated the ability to sustain improvements over time, leading to long-term relief for patients and helping to prevent relapses of depressive symptoms.

Absolutely. Spravato® can be an excellent adjunct to other forms of therapy, such as psychotherapy or counseling, enhancing the overall treatment plan and leading to better outcomes.

Yes, healthcare professionals can tailor the dosage of Spravato® to suit each patient’s specific needs, ensuring optimal treatment outcomes and a personalized approach to care.

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