(949) 996-5355
Book an Appointment
(949) 996-5355
Book an Appointment
  • FDA-Approved At-Home Therapy

Proliv™Rx

in Newport Beach & San Juan Capistrano, CA
The first FDA-approved, prescription, at-home brain neuromodulation therapy for adults with major depressive disorder who haven’t adequately responded to antidepressants.
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Our Approach
  • Understanding Proliv™Rx

What is Proliv™Rx?

Proliv™Rx is the first FDA-approved (Class II PMA), prescription, clinician-directed neuromodulation therapy that can be administered at home. It delivers focal, multi-channel, external Combined Occipital and Trigeminal Afferent Stimulation (eCOT-AS) through a non-invasive wearable headset.

The device applies gentle electrical pulses to targeted neural pathways associated with depression—without invasive procedures and with low risk of systemic side effects. At Resiliency Mind+Body Medicine®, we are proud to be part of the initial rollout of this groundbreaking therapy.

FDA-approved (Class II PMA) for MDD

At-home treatment under physician supervision

Non-invasive with low systemic side effects

App-guided with symptom tracking

At-Home

FDA-Approved Therapy

  • The Challenge

When Antidepressants Aren't Enough

Antidepressants are foundational depression treatment, yet many patients don’t achieve sufficient improvement. After medication failure, recovery likelihood drops significantly. Effective interventional therapies remain limited by geographic constraints, clinic capacity, and extended waitlists—creating a persistent treatment gap.

#1

Leading cause of disability globally

5%

Of US adults experience major depression

700K+

Annual suicide deaths worldwide

30%+

Show treatment resistance to antidepressants

$71B

Estimated annual economic burden in the US

  • The Science

How Proliv™Rx Works

Proliv™Rx uses a non-invasive wearable headset with three pairs of integrated electrodes that contact the scalp on the forehead and occiput, delivering Combined Occipital and Trigeminal Afferent Stimulation (eCOT-AS).

Trigeminal Stimulation

Forehead electrodes stimulate the supraorbital and supratrochlear trigeminal nerve branches bilaterally.

Occipital Stimulation

Rear electrodes stimulate the two greater occipital nerve branches at the back of the head.

Brainstem Pathway

Electrical pulses travel through sensory nerves to the brainstem, then into thalamo-cortical and limbic networks.

Mood Regulation

Signals modulate brain regions involved in mood, arousal, and autonomic regulation to alleviate depression.

  • Your Journey

Clinician-Directed Care at Home

Proliv™Rx shifts treatment from the clinic to your home while preserving full physician oversight.

01

Prescribed by Clinician

Your physician evaluates your history and prescribes Proliv™Rx. The device is delivered to your home.

02

Self-Administer at Home

Wear the headset and follow app-based guidance for correct usage. Treatment is comfortable and non-invasive.

03

App-Guided Tracking

The companion app supports adherence, correct usage, and symptom tracking throughout your treatment.

04

Physician Monitoring

You remain under clinical supervision for ongoing monitoring, dose adjustments, and intervention as needed.

  • Clinical Evidence

The MOOD Study

A multicenter, randomized, double-blind, sham-controlled trial evaluating Proliv™Rx over 16 weeks of home-based self-administration under physician supervision.

10.15

Point Reduction
On the Hamilton Depression Rating Scale (HDRS-17) in the active treatment group

32%

Full Remission
Of initially severe patients who previously failed antidepressants reached full remission (HDRS-17 ≤ 7)

56%

Mild or Depression-Free
At 16 weeks — compared to 0% at baseline. 81% were severe at baseline vs only 15% at 16 weeks.

Lead investigators include Dr. Linda Carpenter (Brown University) and Dr. Mark George (MUSC), among others from UCLA, Northwestern, UNC, and more.

  • Candidacy

Is Proliv™Rx Right For You?

Proliv™Rx is indicated as an adjunctive treatment for adults with major depressive disorder who have not achieved satisfactory improvement from at least one antidepressant medication.

Antidepressant Non-Response

You've tried at least one antidepressant without adequate improvement in depression symptoms.

Occipital StimulationPrefer At-Home Treatment

You want an effective therapy you can do from home without frequent clinic visits.

Non-Invasive Option

You're looking for a non-invasive alternative with low risk of systemic side effects.

  • The Resiliency Difference

Why Choose Resiliency for Proliv™Rx

Early Rollout Partner

We are part of the initial deployment of Proliv™Rx, bringing this breakthrough to our patients first.

Board-Certified Expertise

Led by Dr. LaFrenierre, double board-certified in Psychiatry and Addiction Medicine.

Integrated Treatment

Proliv™Rx alongside Deep TMS, Spravato, VNS, medication management, and lifestyle medicine.

Insurance Support

Our team assists with benefits verification and prior authorization to reduce barriers to care.

  • Common Questions

Frequently Asked Questions

How is Proliv™Rx different from Deep TMS?
Deep TMS requires daily in-clinic sessions over several weeks. Proliv™Rx is prescribed by your clinician but self-administered at home using a wearable headset, eliminating the need for frequent clinic visits while maintaining physician oversight through app-based monitoring.
Yes. Proliv™Rx is an adjunctive treatment, meaning it works alongside your existing antidepressant medications. Your physician will continue to manage your overall treatment plan.
Proliv™Rx has a favorable safety profile with low risk of systemic side effects. Adverse events reported in the clinical trial were mild and transient. Unlike oral medications, the device does not cause the common side effects associated with antidepressants.
Proliv™Rx received FDA approval on January 12, 2026 and is being rolled out through authorized prescribers in early 2026. Resiliency Mind+Body Medicine® is part of the initial deployment. Contact us to learn about availability and get on our interest list.
As a newly FDA-approved device, insurance coverage is being established. Our team will assist with benefits verification and prior authorization. Contact us to discuss coverage options for your specific plan.

Have more questions? Contact our clinical team.

Depression TreatmentFrom Home

Be among the first to access Proliv™Rx at Resiliency Mind+Body Medicine®. Schedule a consultation to learn if this groundbreaking at-home therapy is right for you.
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(949) 996-5355
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