If you or a loved one is suffering from treatment-resistant depression (TRD) or major depressive disorder with suicidal thoughts, SPRAVATO® may offer a new path forward. At Resiliency Mind + Body Medicine, we provide FDA-approved SPRAVATO® (esketamine) therapy in Orange County in a safe, structured environment designed for comfort and clinical supervision. Our mission is to help you achieve lasting mental wellness when traditional medications have failed to bring relief. With convenient locations in Newport Beach and San Juan Capistrano, our patients in Orange County enjoy convenient access and flexible scheduling to get their depression into remission.
Spravato® is a nasal spray formulation of esketamine, a medication derived from ketamine. Unlike traditional antidepressants, which target serotonin and norepinephrine, Spravato® works on the glutamate system—specifically the NMDA receptor. This novel mechanism restores synaptic connections in the brain and promotes neuroplasticity, which may help “rewire” patterns associated with depression.
When nothing works, try what works differently.
Spravato® is FDA-approved to treat:
It is administered under direct medical supervision, making it both powerful and safe when delivered by experienced mental health providers.
With 2 convenient locations in Orange County, Newport Beach and San Juan Capistrano, our unique clinic offers a comprehensive, integrative approach to mental health, setting us apart as a destination for advanced psychiatric care in Orange County.
Spravato® is administered in-office twice weekly for the first four weeks, followed by a tapering schedule based on your provider’s recommendation.
Your treatment plan is customized to your clinical needs, with regular evaluations of your mood, side effects, and progress.
Spravato® is not a first-line treatment. It is intended for:
Spravato® is not appropriate for individuals with:
Certain cardiovascular or psychiatric conditions (your eligibility is reviewed during a full intake evaluation)
Unlike traditional SSRIs or SNRIs, which may take 4–8 weeks to show effects, many Spravato® patients report symptom relief within hours or days of their first treatment.
For those in acute crisis or with long-standing depression, Spravato® may be life-changing.
Esketamine, the active ingredient in Spravato®, acts as an NMDA receptor antagonist, influencing glutamate, the most abundant neurotransmitter in the brain. This action will stimulate synaptogenesis (the formation of new synapses), which plays a critical role in repairing the brain’s mood regulation pathways.
Unlike oral antidepressants, Spravato® bypasses the digestive tract and delivers rapid-onset neurochemical changes in the brain—ideal for patients who need fast results.
Resiliency Mind + Body Medicine is located in Newport Beach and San Juan Capistrano, CA serving patients across:
Our clinics offer free parking, a welcoming front desk team, and flexible weekday scheduling to make your treatment seamless and supportive.
Yes, most commercial insurers cover Spravato® if the criteria for treatment-resistant depression are met. Our staff will assist with benefit verification and prior authorizations.
Spravato® is esketamine, a purified form of ketamine, specifically approved by the FDA for depression and administered only in certified clinics.
No. Spravato® is a nasal spray, not an IV infusion. It is dosed and monitored under strict FDA guidelines.
After an intake evaluation and insurance approval, treatment may begin in as little as 1–2 weeks.
Ready to take the next step? Schedule a consultation today to learn more about how we can help you achieve your health and wellness goals. Our team is here to provide you with the information you need to make informed decisions about your care.
